کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065606 1580484 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Murine hematopoietic stem cells and progenitors express adrenergic receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Murine hematopoietic stem cells and progenitors express adrenergic receptors
چکیده انگلیسی

Association between the nervous and immune system is well documented. Immune cells originate within the bone marrow that is innervated. Thermal injury induces adrenergic stimulation, augments monocytopoiesis and alters the β-adrenergic receptor (AR) profile of bone marrow monocyte committed progenitors. This provides an impetus to study AR expression in hematopoietic progenitors along myeloid lineage. Using FACS analysis and confocal microscopy, we report the expression of α1-, α2- and β2-AR in enriched populations of ER-MP20+ and ER-MP12+ myeloid progenitors, CD117+ and CD34+ multi-potential progenitors and more importantly pluripotent stem cells suggesting a plausible role for catecholamine in hematopoietic development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 186, Issues 1–2, May 2007, Pages 27–36
نویسندگان
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