کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065844 1580488 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trail interacts redundantly with nitric oxide in rat astrocytes: Potential contribution to neurodegenerative processes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Trail interacts redundantly with nitric oxide in rat astrocytes: Potential contribution to neurodegenerative processes
چکیده انگلیسی
The proapoptotic cytokine TRAIL has been shown to enhance amyloid-β-dependent neurotoxicity. Here are reported interactions between TRAIL and nitric oxide (NO) in cultured rat astrocytes in vitro. Rat astrocytes expressed all TRAIL receptor mRNAs and proteins. However, TRAIL failed in inducing apoptosis of astrocytes, whereas these cells released substantial amounts of nitrites. A TRAIL-neutralizing antibody was able to prevent LPS-induced iNOS expression in astrocytes. Interestingly, TRAIL induced its own expression in astrocytes. These data suggest that redundancy between TRAIL and NO in astrocytes could be fueling neuronal damage/death processes, potentially uncovering novel molecular targets for the treatment of neurodegenerative disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 182, Issues 1–2, January 2007, Pages 41-47
نویسندگان
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