کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065848 | 1580488 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity](/preview/png/3065848.png)
چکیده انگلیسی
For the study of malignant glioma, we have previously characterized a highly tumorigenic murine astrocytoma, SMA-560, which arose spontaneously in an inbred, immunocompetent VM/Dk mouse. Using this cell line as a model of murine glioma, we performed DNA microarray analysis of autologous normal murine astroctyes (NMA) and SMA-560 tumor cells grown in monolayer culture or intracranially in syngeneic immunocompetent or immunocompromised hosts in order to determine whether tumors grown in vitro recreate the complex genetic regulation that occurs in vivo. Our findings support our hypothesis that glioma phenotype in vitro may be quite different in vivo and significantly altered by in situ growth factors and other invading cell populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 182, Issues 1–2, January 2007, Pages 63–72
Journal: Journal of Neuroimmunology - Volume 182, Issues 1–2, January 2007, Pages 63–72
نویسندگان
Chris A. Learn, Peter M. Grossi, Robert J. Schmittling, Weihua Xie, Duane A. Mitchell, Isaac Karikari, ZhengZheng Wei, Holly Dressman, John H. Sampson,