Longitudinal analysis of activation markers on monocyte subsets during the development of simian immunodeficiency virus encephalitis

Lentiviral encephalitis has been hypothesized to be associated with altered monocyte migration into the brain. CD14hi/CD16lo and CD14lo/CD16hi monocytes were expanded during acute infection; however, this expansion was not unique or greater in macaques that developed encephalitis. The proportion of monocytes that expressed CD62L, HLA-DR, CD16, CD64, and CD40 varied during the course of infection in macaques that eventually developed encephalitis. Taken together, these results suggest that changes in the proportion of circulating activated monocytes are not predictive of development of encephalitis, but this does not rule out the importance of activated monocytes in the development of encephalitis.