کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065957 1580491 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibody-mediated neuronal cell signaling in behavior and movement disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Antibody-mediated neuronal cell signaling in behavior and movement disorders
چکیده انگلیسی

Behavioral and movement disorders may have antibody responses where mimicry and signal transduction may lead to neuropsychiatric abnormalities. In our study, antibodies in pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS) reacted with the neuronal cell surface and caudate–putamen and induced calcium–calmodulin dependent protein (CaM) kinase II activity in neuronal cells. Depletion of serum IgG abrogated CaM kinase II cell signaling and reactivity of CSF was blocked by streptococcal antigen N-acetyl-beta-d-glucosamine (GlcNAc). Antibodies against GlcNAc in PANDAS sera were inhibited by lysoganglioside GM1. Results suggest that antibodies from an infection may signal neuronal cells in some behavioral and movement disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 179, Issues 1–2, October 2006, Pages 173–179
نویسندگان
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