کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065982 | 1580492 | 2006 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD28−CD57+ T cells predominate in CD8 responses to glatiramer acetate
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Human T cells adopt a CD28−CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57−Perforin−. This changed to a predominantly CD28−CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 178, Issues 1–2, September 2006, Pages 117–129
Journal: Journal of Neuroimmunology - Volume 178, Issues 1–2, September 2006, Pages 117–129
نویسندگان
Robert B. Ratts, Amy E. Lovett-Racke, Judy Choy, Sara C. Northrop, Rehana Z. Hussain, Nitin J. Karandikar, Michael K. Racke,