کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065987 | 1580492 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The thymus is a source of B-cell-survival factors–APRIL and BAFF–in myasthenia gravis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The accumulation of B cells in the thymus is a common feature of myasthenia gravis (MG). To understand whether factors enhancing B-cell survival are increased in MG, we studied the expression of APRIL, BAFF and three of their receptors in the thymus. In hyperplastic thymi, macrophages expressed APRIL and BAFF, and germinal-center B cells, BAFF-R. CD138-positive plasma cells were abundant in MG thymi. By contrast, BCMA-positive plasma cells were scarce. The expression of APRIL and BAFF in MG thymi may reflect the establishment of an environment favorable to B-cell survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 178, Issues 1–2, September 2006, Pages 161–166
Journal: Journal of Neuroimmunology - Volume 178, Issues 1–2, September 2006, Pages 161–166
نویسندگان
Mathula Thangarajh, Thomas Masterman, Lars Helgeland, Uroš Rot, Malin V. Jonsson, Geir Egil Eide, Ritva Pirskanen, Jan Hillert, Roland Jonsson,