کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065988 1580492 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential scope of action of tissue kallikreins in CNS immune-mediated disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Potential scope of action of tissue kallikreins in CNS immune-mediated disease
چکیده انگلیسی

The objective of this study was to define the potential scope of action of tissue kallikreins in T cell-mediated disease of the CNS. We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 178, Issues 1–2, September 2006, Pages 167–176
نویسندگان
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