کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3066075 1580498 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The adrenal gland is a source of stress-induced circulating IL-18
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The adrenal gland is a source of stress-induced circulating IL-18
چکیده انگلیسی

The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 172, Issues 1–2, March 2006, Pages 59–65
نویسندگان
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