کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3066119 | 1580495 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma](/preview/png/3066119.png)
چکیده انگلیسی
We examined the serum levels of cytokines, interferon (IFN)-α, IFN-γ, interleukin (IL)-4, IL-12 p40, and IL-12 p70; those that affect the T helper 1 and 2 balance in patients with myasthenia gravis (MG). Among the cytokines tested, only IL-12 p40, together with the serum titer of anti-IL-12 p40 antibody, was significantly elevated in MG with thymoma. Their elevation was independent of the histopathology of thymoma. Thymectomy decreased the levels of IL-12 p40 accompanied by the anti-acetylcholine receptor antibody, but not anti-IL-12 p40 antibodies. These data strongly suggest the association of IL-12 p40 and its autoantibody with the immunopathology of MG with thymoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 175, Issues 1–2, June 2006, Pages 169–175
Journal: Journal of Neuroimmunology - Volume 175, Issues 1–2, June 2006, Pages 169–175
نویسندگان
Hiroaki Yoshikawa, Katsuaki Sato, Shigeki Edahiro, Yutaka Furukawa, Takahiro Maruta, Kazuo Iwasa, Hideto Watanabe, Shizuka Takaoka, Yasuhiro Suzuki, Masaharu Takamori, Masahito Yamada,