کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3074539 | 1188880 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional pathway-defined MRI diffusion measures reveal increased transverse diffusivity of water in multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
The diffusion properties of water are sensitive to microscopic changes in the white matter of multiple sclerosis (MS) patients. Typical MRI measures of disease burden in MS demonstrate modest to poor correlation with disability. Functional MRI and DTI-based fiber tracking were used to define the interhemispheric white matter pathway connecting bilateral supplementary motor areas (SMA) in 16 MS patients sand 16 control subjects. Fractional anisotropy (FA), mean diffusivity (MD), longitudinal (λ1) and transverse diffusivity (λ2) were measured along this pathway in all subjects. Mean FA was 0.587 ± 0.032 for patients and 0.608 ± 0.020 for controls (P < 0.02). Mean MD was (0.821 ± 0.055) Ã 10â3 mm2 sâ1 for patients and (0.770 ± 0.020) Ã 10â3 mm2 sâ1 for controls (P < 0.004). Mean λ1 values were (1.462 ± 0.099) Ã 10â3 mm2 sâ1 for patients and (1.400 ± 0.034) Ã 10â3 mm2 sâ1 for controls (P < 0.02). Mean λ2 values were (0.500 ± 0.047) Ã 10â3 mm2 sâ1 for patients and (0.454 ± 0.027) Ã 10â3 mm2 sâ1 for controls (P < 0.001). In addition, the correlation between the Multiple Sclerosis Functional Composite (MSFC) and transverse diffusivity was â0.341 (P < 0.05). The component test of the MSFC most related to the SMA pathway studied with our MRI method (Nine-hole Peg Test) showed significant correlation with transverse diffusivity (r = 0.392, P < 0.02), indicating that probing functional pathways with MRI measures can lead to a better reflection of disease status.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 32, Issue 3, September 2006, Pages 1127-1133
Journal: NeuroImage - Volume 32, Issue 3, September 2006, Pages 1127-1133
نویسندگان
Mark J. Lowe, Craig Horenstein, Jochen G. Hirsch, Ruth Ann Marrie, Lael Stone, Pallab K. Bhattacharyya, Achim Gass, Micheal D. Phillips,