The risk for end-stage renal disease is increased after burn

• The risk for end-stage renal disease after burn is increased significantly.
• Principally women patients have an increased risk for end-stage renal disease after burn.
• The increased incidence of end-stage renal disease seems to be independent of acute kidney injury.
• The risk of end-stage renal disease may be related with pre-existing chronic kidney disease.

ObjectiveAcute kidney injury (AKI) commonly complicates burn. Recently, AKI has been suggested to be causally related to chronic end-stage renal disease (ESRD), but controversial data also exist. Our aim was to study the risk of ESRD after burn in a nationwide analysis.MethodsAll burn patients undergoing hospitalization between 1998 and 2011 were identified from the National Hospital Discharge Register, and the data were linked with the Finnish Registry for Kidney Diseases, which includes all individuals receiving chronic renal replacement therapy (RRT) in Finland.ResultsAltogether 41,179 adults were treated at hospitals for burns in Finland between 1998 and 2011. Of these, 86 had a diagnosis of AKI related to the burn. Forty-three burn survivors had ESRD and RRT initiated related to or after the burn. The overall risk for ESRD after burn was increased (standardized incidence ratio, SIR, 2.40, 95% CI 1.73–3.23) compared with the Finnish population. Standardized incidence ratio was 3.11 (95% CI 1.66–5.32) in women and 1.89 (95% CI 1.27–2.69) in men. Of these 43 patients, 38 had a specific non-burn-related diagnosis of ESRD identified in the registry, and ESRD was deemed unlikely to be directly related to the burn. In five patients, the diagnosis of ESRD was unknown cause of renal failure, and causality of the burn with ESRD was evaluated as plausible.ConclusionIn conclusion, a significantly increased risk of ESRD was recorded after a severe burn. Our results do not support increased incidence of ESRD solely as a consequence of AKI due to burn, but burn may increase the risk of ESRD in patients with pre-existing chronic kidney disease.