کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3106091 1191701 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prospective clinical and experimental studies on the cardioprotective effect of ulinastatin following severe burns
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Prospective clinical and experimental studies on the cardioprotective effect of ulinastatin following severe burns
چکیده انگلیسی

ObjectiveTo investigate the preventive effect of ulinastatin on shock in the heart after burn.MethodsIn an open prospective clinical study 34 adults with burns >50% total body surface area were randomly divided into control (B) and ulinastatin-treated (U) groups. All underwent routine treatment, and group U received 100,000 U ulinastatin intravenously three times a day for 1 week. In an animal experiment, 72 healthy rats underwent equivalent burn, similar division into groups B and U, and resuscitation according to Parkland's formula. Rats in group U received ulinastatin (40,000 U/kg) immediately after burn. Myocardial pathomorphology, plasma cTnI, CK-MB and PMNE, myocardial MDA, TNF-α, IL-10 and caspase-3 activity and cardiocyte apoptosis were determined.ResultsPlasma cTnI, CK-MB, and PMNE were higher in clinical group B than group U. In the animal experiment, plasma cTnI, CK-MB, myocardial MDA, TNF-α, IL-10 and caspase-3 activity, and apoptotic index and myocardial pathomorphological changes were significantly less in group U than in group B, save IL-10.ConclusionThe clinical and experimental data showed that ulinastatin relieved myocardial damage from severe burn. The mechanism might involve modulation of the anti- and pro-inflammatory balance and lipid peroxidation, and decreased myocardiocyte apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 34, Issue 5, August 2008, Pages 674–680
نویسندگان
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