کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3108651 | 1192032 | 2008 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pathophysiology of Delirium in the Intensive Care Unit
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
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چکیده انگلیسی
Delirium, or acute brain dysfunction, is a life-threatening global disturbance in cognitive functioning that frequently manifests in critically ill patients. This review examines the current status of knowledge regarding the pathophysiology of delirium in the ICU, in particular, evaluating the role of iatrogenic factors such as sedatives and analgesic administration in brain dysfunction. This hypothesis is considered along with several other plausible mechanisms of ICU delirium, including sepsis, postoperative cognitive dysfunction, and changes in biomarkers and neurotransmitters. The review concludes by highlighting potential future directions in molecular genetics for the elucidation of delirium and its long-term consequences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Care Clinics - Volume 24, Issue 1, January 2008, Pages 45–65
Journal: Critical Care Clinics - Volume 24, Issue 1, January 2008, Pages 45–65
نویسندگان
Max L. Gunther, Alessandro Morandi, E. Wesley Ely,