Simvastatin Alleviates the Progression of Periapical Lesions by Modulating Autophagy and Apoptosis in Osteoblasts

We found a negative relation between autophagy and apoptosis in osteoblastic cells. In addition, simvastatin suppressed apoptosis and enhanced autophagy both in vitro and in vivo. Our data implied that simvastain might alleviate the progression of apical periodontitis by promoting autophagy to protect osteoblasts from turning apoptotic.