Conventional mechanical periodontal therapy - A pioneering and nontoxic experimental model for the study of acute human inflammatory response *

In the past decade, the association of periodontal diseases with the development of systemic diseases has received increasing attention. A variety of recent hypothesis driven investigations have compiled various results showing that periodontal infection and subsequent direct oral-haematogenous spread of bacteria are implicated in the development of inflammation and various systemic diseases. Chronic periodontitis causes a low-grade systemic inflammatory response; its standard treatment, however, induces an acute inflammatory response. The aim of this study was to describe the systemic inflammatory reactions to an intensive periodontal treatment regimen.