کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
31648 | 44827 | 2013 | 7 صفحه PDF | دانلود رایگان |
Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of α-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.
► Engineering of the yeast central carbon metabolism to develop a platform cell factory.
► More efficient provision of the precursor metabolite acetyl-CoA.
► The platform cell factory can be used for improving α-santalene production by four-fold.
Journal: Metabolic Engineering - Volume 15, January 2013, Pages 48–54