کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3167070 1199350 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD27 and CD38 lymphocytes are detected in oral lichen planus lesions
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
CD27 and CD38 lymphocytes are detected in oral lichen planus lesions
چکیده انگلیسی

ObjectiveOral lichen planus (OLP) is a chronic disease with bandlike lymphocyte infiltration.Study designTo elucidate the immunologic phenotype of OLP, we analyzed the presence of CD5+, CD20+, CD27+ and/or CD38+ lymphocytes in a series of 70 atrophic OLP biopsy samples.ResultsCD27+ and CD38+ cells were present in 84% and 54% of the lesions, respectively. The lesions were graded as T-cell dominant, B-cell dominant, or a mixed lesion based on CD5+ and CD20+ cells in the inflammatory infiltration with the following results: 26%, 7%, and 67%, respectively. CD27 expression was found in 67% of the T-cell dominant, in 80% of the B-cell dominant, and in 91% of mixed lesions. The corresponding figures for CD38 were 72%, 80%, and 62%.ConclusionsCD27+ and CD38+ lymphocytes represent abnormal mononuclear cell populations in atrophic OLP lesions indicating 2 forms of OLP might exist with different pathogenesis, despite similar histology and clinical behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 111, Issue 2, February 2011, Pages 211–217
نویسندگان
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