کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3167418 | 1199364 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma](/preview/png/3167418.png)
ObjectiveThe aim of this study was to elucidate changes in interleukin-6 (IL-6) levels in whole saliva during the treatment of patients with oral squamous cell carcinoma (OSCC).Study designTwenty-nine consecutive inpatients with OSCC were enrolled. Stimulated saliva was collected just after hospitalization (period 1), just before main treatment (surgery in 26 cases; period 2), and at the time of discharge (period 3). The mean intervals were 11 ± 8 days between periods 1 and 2 and 30 ± 18 days between periods 2 and 3. Nineteen age-matched healthy control subjects were also recruited. Interleukin-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay.ResultsInterleukin-6 was detected in 23 out of 29 samples in the OSCC group in period 1. The concentration of IL-6 was significantly higher in the OSCC group (mean 20.1 ± 36.3 pg/mL) than in the control subjects (0.6 ± 0.8 pg/mL; P = .003). The mean concentration of IL-6 at period 2 was 43.6 ± 95.6 pg/mL, significantly higher than at period 1 (P = .002), and at period 3 was 17.1 ± 27.6 pg/mL (P = .52 [compared with period 2]).ConclusionsInterleukin-6 was up-regulated in saliva in the OSCC patients. The IL-6 level tended to increase before treatment, and it returned to baseline levels after treatment.
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 110, Issue 3, September 2010, Pages 330–336