کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3167562 1199367 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Starvation survival and recovery in serum of Candida albicans compared with Enterococcus faecalis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Starvation survival and recovery in serum of Candida albicans compared with Enterococcus faecalis
چکیده انگلیسی

ObjectiveCandida albicans has been a common isolate in posttreatment disease, usually as a monoinfection of the root filled canal. A factor likely to contribute to its pathogenic potential in posttreatment infection is an ability to endure starvation and use serum as a nutritional source. This study evaluated the starvation-survival behavior, growth, and recovery in human serum of C. albicans and compared it with Enterococcus faecalis.Study designVarying cell densities of C. albicans and E. faecalis were suspended in 5% human serum or water for 4-6 months. Starvation recovery was assessed by addition of 50% serum to starved cells. Cell survival was monitored by periodic removal of aliquots and viable counts.ResultsInitial cell density was important for starvation survival. Candida albicans and E. faecalis survived starvation in water for 6 months when the starting cell density was >105 and ≥108 colony-forming units (cfu)/mL, respectively. Both species thrived in 5% serum from low initial densities (>102 and >104 cfu/mL for C. albicans and E. faecalis, respectively), and starvation-state cells recovered on addition of 50% serum.ConclusionCandida albicans is well suited for survival in nutrient-limited conditions and can use serum as a source of nutrition and for recovery from starvation. These findings parallel the behavior of E. faecalis, which possesses a similar capacity for starvation survival and growth in serum, traits that are of likely importance for their participation in posttreatment infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 110, Issue 1, July 2010, Pages 125–130
نویسندگان
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