کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3167641 1199375 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws
چکیده انگلیسی

ObjectivesIt is well established that fibrous dysplasia (FD) is caused by mutations of the Arg201 codon of the GNAS gene. However, the role of GNAS mutation in the pathogenesis of cement-osseous dysplasias (COD) and cemento-ossifying fibromas (COF) is not fully known. In this study, we examined COD and COF for mutations at the Arg201 codon of the GNAS gene.Study designThe study sample included formalin-fixed, paraffin-embedded tissue blocks from 8 COF and 24 COD. We used 2 PCR-RFLP methods to detect mutations at the Arg201 codon of the GNAS gene.ResultsMutations at the Arg201 codon of the GNAS gene were not present in any of the COD and COF examined.ConclusionsGNAS mutations do not play a role in the pathogenesis of COD and COF. This highlights a clear molecular distinction between FD and other histologically similar fibro-osseous lesions of the jaws.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 109, Issue 5, May 2010, Pages 739–743
نویسندگان
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