کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3167735 1199377 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of sidestream dark-field (SDF) imaging for assessing the effects of high-dose melphalan and autologous stem cell transplantation on oral mucosal microcirculation in myeloma patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Use of sidestream dark-field (SDF) imaging for assessing the effects of high-dose melphalan and autologous stem cell transplantation on oral mucosal microcirculation in myeloma patients
چکیده انگلیسی

BackgroundOral mucositis (OM) is a common toxic side effect among patients receiving high-dose chemotherapy (CT) with autologous stem cell transplantation (ASCT) for hematologic malignancies. The aim of this study was to investigate changes in submucosal microcirculation in myeloma patients receiving high-dose CT with ASCT by assessing capillary density and microvascular structural integrity.MethodsTen consecutive patients with multiple myeloma who underwent first-time CT treatment with high-dose melphalan (200 mg/m2) and ASCT were included in this study. Baseline buccal mucosa capillary density, expressed as the mean number of capillaries ± SD per mm2 (cpll/mm2), was measured with sidestream dark-field imaging after treatment was performed, after 30 and 60 minutes, and then on days 2, 4, 6, 8, and 14. A linear mixed model was used to examine capillary density over time and a P value of <.05 was considered to be statistically significant.ResultsBaseline mucosal capillary density was 19 ± 2.4 cpll/mm2. Mucosal capillary density after melphalan infusion after 30 and 60 minutes and on days 2 and 4 showed no statistically significant differences. A decrease in capillary density with statistical significance was observed on days 6 (10 ± 3.0 cpll/mm2; P < .01) and 8 (12 ± 4.9 cpll/mm2; P < .01). On day 14, capillary density returned to near baseline value.ConclusionsHigh-dose CT alters microvascular structural integrity and dysregulates tissue perfusion in the oral mucosa by decreasing the number of perfused submucosal capillaries in the oral mucosa. The findings of this investigation suggest that acute CT toxicity alters oral microcirculation and may be an important mechanism responsible for driving early mucosal barrier disturbances associated with CT-induced OM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 109, Issue 1, January 2010, Pages 91–97
نویسندگان
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