کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3167824 1199379 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effectable application of vascular endothelial growth factor to critical sized rat calvaria defects
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Effectable application of vascular endothelial growth factor to critical sized rat calvaria defects
چکیده انگلیسی

ObjectiveAn early vascular response for angiogenesis is essential for the normal progression of bone defect healing. Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis. The aim of this study was to evaluate the effects of a poly (L,D-lactic-co-glycolic acid) (PLGA) membrane with VEGF encapsulated into PLGA microspheres on bone regeneration at bone defects in rat calvaria.Study DesignMicrospheres of PLGA incorporating VEGF165 (VEGF microspheres) were prepared, and critical-size bone defects were created in rat calvaria. The VEGF microspheres, PLGA microspheres, or VEGF microspheres plus PLGA membrane were applied to the defects. Bone regeneration was evaluated using image analysis based on soft radiographic and histologic examination.ResultsMature thick bone regeneration was observed in selected sites at bone defects that had been applied with VEGF microspheres/PLGA membrane compared with those that had been applied with the other treatments.ConclusionA combination of VEGF microspheres and a PLGA membrane effectively enhances bone regeneration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 109, Issue 2, February 2010, Pages 225–231
نویسندگان
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