کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3167971 | 1199387 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preclinical animal model for de novo bone formation in human maxillary sinus Preclinical animal model for de novo bone formation in human maxillary sinus](/preview/png/3167971.png)
ObjectivesUp to now the effect of bone-substitute materials on de novo bone formation has been tested in a variety of preclinical animal models. We hypothesized that there is no significant difference in bone regeneration after application of autogenous bone (AB) and bone substitutes in a porcine calvarial monocortical defect model and in human maxillary sinus.Study designTwenty-four weeks after application of ß-tricalcium phosphate (βTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11× βTCP, 6× HA and 24× AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis.ResultsComparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found.ConclusionThe chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery.
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 108, Issue 3, September 2009, Pages e37–e44