کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3168499 1199417 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mesenchymal stem cells enhance bone regeneration in rat calvarial critical size defects more than platelete-rich plasma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Mesenchymal stem cells enhance bone regeneration in rat calvarial critical size defects more than platelete-rich plasma
چکیده انگلیسی

ObjectiveThe objective of this study was to compare culture-expanded bone marrow–derived mesenchymal stem cell and PRP loaded to natural bone mineral (Bio-Oss) and β-TCP for rat calvarial bone repair.MethodsTwenty-two adult male Sprague-Dawley rats were randomly divided into 2 groups (n = 11). In the first group, 2 calvarial defects, 5 mm in diameter, were prepared in the parietal bone. The left defect was filled with Bio-Oss plus PRP while the right defect was filled with mesenchymal stem cell cultured on Bio-Oss. Kasios as a bone substitute was replaced in the second group. The animals were humanely killed 6 weeks postsurgery and the amount of the bone regeneration evaluated using histometric analysis.ResultThe bone fill length in the calvarial defect had statistically significant difference with other groups (P < .05). In both groups, mesenchymal stem cell revealed a higher percentage of bone formation in comparison with the PRP groups.ConclusionsNew synthetic bone substitutes may offer a better condition for bone regeneration compared to the traditional bone substitute in combination with mesenchymal stem cells. They remained in the defect and contributed bone regeneration. The use of the mesenchymal stem cell in conjunction with bone substitutes can enhance bone regeneration more than PRP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 106, Issue 3, September 2008, Pages 356–362
نویسندگان
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