کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3168520 1199417 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Labial salivary gland biopsies in Sjögren's syndrome: still the gold standard?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Labial salivary gland biopsies in Sjögren's syndrome: still the gold standard?
چکیده انگلیسی

ObjectivesThe accuracy and diagnostic benefits of the labial salivary gland (LSG) biopsy for Sjögren's syndrome (SS) have received mixed reviews. This study was conducted to assess (1) the inter-rater agreement among 5 pathologists, and (2) the relationship between biopsy findings and clinical disease parameters.Study designThree oral pathologists (OP) and two surgical pathologists (SP) provided independent diagnoses, focus scores, and plasma cell characterizations for 37 LSG biopsies. Inter-rater reliability was assessed using percentage of overall agreement and intraclass correlation coefficients. Relationships between diagnoses and clinical parameters were assessed by nonparametric correlations.ResultsOverall agreement among the pathologists was poor, although the intra-specialty agreement was good. The ratings of OP were most highly correlated with serological measures, while those of SP were correlated with salivary flow rate and disease damage.ConclusionSince the LSG biopsy can be the determining factor in SS diagnoses, these demonstrated inconsistencies merit further consideration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 106, Issue 3, September 2008, Pages 392–402
نویسندگان
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