Leiomyomatous hamartoma: report of two cases and review of the literature

Two cases of leiomyomatous hamartoma (LH) in patients of Latin ancestry are reported here. The first lesion was detected on the incisive papilla of a 19-year-old woman; this is an unusual age because these lesions are commonly observed during the first years of life. The second lesion found on the middle-dorsum of the tongue was observed in a 5-month-old boy. The diagnosis was based on the histopathological appearance and confirmed by immunohistochemistry with positivity for smooth muscle actin, muscle-specific actin, S-100 protein and desmin. To date, only 16 cases have been reported in the English-language literature. Controversial epidemiological data, histogenesis, clinical/histopathological features, and differential diagnosis are discussed herein.