کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3168902 1199438 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytomorphometric and immunohistochemical comparison between central and peripheral giant cell lesions of the jaws
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Cytomorphometric and immunohistochemical comparison between central and peripheral giant cell lesions of the jaws
چکیده انگلیسی

ObjectiveTo determine whether cytomorphometric differences of multinucleated giant cells (MGCs) and CD68 reactivity of both MGCs and infiltrating macrophages may be associated with the clinical behavior of central and peripheral giant cell lesions of the jaws.Study designParaffin-embedded samples of central giant cell lesions (CGCLs; n = 20) and peripheral giant cell lesions (PGCLs; n = 20) were prepared for cytomorphometric analysis and immunohistochemistry.ResultsThe nuclei in CGCLs were more numerous, larger, and more irregular than those in PGCLs. Furthermore, CD68 expression and the ratio of CD68+ macrophage to MGCs were significantly greater in CGCLs than in PGCLs. Statistical correlations between CD68 expression and the staining-intensity distribution score within the diagnostic groups were significant in CGCLs and not significant in PGCLs.ConclusionAlthough the CGCLs share some histopathologic similarities with PGCLs, differences in both nuclear morphometric parameters of MGC and CD68 immunoreactivity may underlie the distinct clinical behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 105, Issue 5, May 2008, Pages 625–632
نویسندگان
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