In vivo evaluation of the biocompatibility of a new resin-based obturation system

ObjectiveThe aim of this study was to evaluate the in vivo biocompatibility of the new resin-based Epiphany-Resilon root canal filling system after implantation in rat connective tissue.Study designThirty-six female Wistar albino rats, 9 months old, weighing 200 to 220 g, were used to evaluate the biocompatibility. Four subcutaneous pockets were created in the back of the rats, and each material (Resilon, gutta-percha, a Teflon tube containing Epiphany, and an empty Teflon tube) was implanted into a specific dorsal site. The empty Teflon tubes were used as control. After 1, 4, and 8 weeks, the implants were removed with the surrounding tissues. The inflammatory tissue reactions were graded after a histopathologic examination.ResultsAt each time period, there was practically no difference in the reaction of all the implant materials (P > .05). The intensity of the reaction had diminished by the 4-week observation period, and this reduction continued through the 8-week observation period.ConclusionAll the tested materials showed an acceptable biocompatibility.