کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3169465 | 1199477 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Efficacy of lycopene in the management of oral submucous fibrosis Efficacy of lycopene in the management of oral submucous fibrosis](/preview/png/3169465.png)
ObjectivesTo evaluate the efficacy of oral lycopene therapy in patients with oral submucous fibrosis and to compare these effects with a placebo.Study designFifty-eight patients with oral submucous fibrosis formed the population for the study and were randomly divided into 3 groups, evaluated weekly over a 2-month period. Patients of group A (n = 21) received 16 mg of lycopene, those of group B (n = 19) received 16 mg of lycopene along with biweekly intralesional steroid injections, and those of group C (n = 18) were given a placebo. Paired and unpaired t tests were used for statistical evaluation.ResultsMouth-opening values for the patients showed an average increase of 3.4 mm, 4.6 mm, and 0.0 mm for patients in groups A, B, and C, respectively. These values were statistically found to be highly significant.ConclusionsThe observed effects suggest that lycopene can and should be used as a first line of therapy in the initial management of oral submucous fibrosis.
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 103, Issue 2, February 2007, Pages 207–213