Correlation of tuned aperture computed tomography with conventional computed tomography for evaluation of osseous healing in calvarial defects

ObjectiveTo compare the diagnostic efficacy of iteratively restored tuned aperture computed tomography (TACT) with conventional computed tomography (CT) for evaluation of osseous healing in induced calvarial defects.Study designFifty-six calvarial defects in 14 rabbits received 1 of 4 possible treatments: copolymer membranes with and without bone marrow stromal cells (BMSCs), BMSCs alone, or no treatment (control). Healing was measured after 2, 4, and 8 wks as remaining defect areas measured on TACT and CT images. Histomorphometric analyses were done on the specimens.ResultsBone formation was minimal to none in control defects and those treated with BMSCs or polymer matrices alone. Healthy bone formation was noted in defects treated with polymers impregnated with BMSCs. Unresolved defect area measurements using TACT and CT of osseous healing showed a high positive correlation.ConclusionsPotential for TACT to accurately detect osseous healing in surgical defects was demonstrated. High resolution of TACT combined with generation of information in 3D yields comparable performance to CT.