کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3169799 1199497 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Macroscopical, histological, and morphometric studies of porous bone-replacement materials in minipigs 8 months after implantation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Macroscopical, histological, and morphometric studies of porous bone-replacement materials in minipigs 8 months after implantation
چکیده انگلیسی

ObjectiveThe aim of this investigation was to test the induction of bone formation and biodegradation of different biomaterials based on calcium phosphate (CaP). Up to now, hydroxyapatite and β-tricalcium phosphate ceramics have routinely been sintered at temperatures of 1300°C. The new CaP biomaterials tested are fabricated by a sol-gel process at only 700°C.Study designCritical-size defects (>5 cm3) in the mandible of 15 adult Goettingen minipigs were filled with 1 of the 2 new types of CaP biomaterials, or with 1 of 2 well-known old-type ceramics, or with a gelatin sponge (in the control group). Macroscopical, histological, and morphometric examination of the former defect areas were made 8 months postoperatively.ResultsEight months after implantation of the new CaP biomaterials, complete bone formation was observed in the defect area, and at the same time, the foreign material was resorbed almost completely. After implantation of the classical types of ceramics, only incomplete bone formation and a lesser resorption rate of the foreign bodies were noted. The difference in the bone formation rate was significant: more than 93% for the new CaP biomaterials versus less than 58% for the classical types of ceramics (P < 0.01).ConclusionThe biological behavior of the new CaP biomaterials was better than that of the old-type sintered ceramic bone-grafting materials. These new CaP matrices are suitable for filling bone defects and are of interest for dentists, including implantologists, craniomaxillofacial and orthopedic surgeons, as well as traumatologists.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 102, Issue 5, November 2006, Pages 606–613
نویسندگان
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