کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3169839 1199498 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The monocortical critical size bone defect as an alternative experimental model in testing bone substitute materials
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
The monocortical critical size bone defect as an alternative experimental model in testing bone substitute materials
چکیده انگلیسی

BackgroundReproducibility and comparability are prerequisites in testing bone substitute materials in an animal study. Various animal test models are used. The standard in testing bone substitute materials is the so-called critical size defect (CSD) model described by Schmitz and Hollinger. In most studies a bicortical (full thickness defect) CSD is used.ObjectiveIn this study, monocortical defects (10 × 10 mm) in calvarias of adult pigs were created and compared to examine the spontaneous physiologic healing process and the required criteria for a CSD.Study designRegeneration of defects, either filled using autogenous bone (group 1) or unfilled (group 2), was evaluated by means of microradiography and light microscopy after 2, 4, 12, 26, and 52 weeks.ResultsNo complete osseous regeneration was found microradiographically and light microscopically in the control group at week 52 (nonmineralized area: 30% ± 1.7%; mineralized area: 55% ± 1.7%; bone marrow area: 15% ± 1.7%). Defects treated with autogenous bone showed a 100% osseous defect filling after 26 weeks.ConclusionThe monocortical CSD fulfills the requirements for a CSD and represents a procedure which can be handled simply for investigations focusing on bone regeneration and testing of bone substitute materials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 102, Issue 1, July 2006, Pages 7–13
نویسندگان
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