کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3170007 | 1199501 | 2006 | 5 صفحه PDF | دانلود رایگان |
ObjectiveThe aim of this study was to compare the effects of platelet-rich plasma (PRP) and platelet-enriched fibrin glue on bone formation in bone tissue engineering.Study designPRP was mixed with bone marrow mesenchymal stem cells and bone morphogenetic protein-2 (BMP-2), and the composites were injected into the subcutaneous space on the dorsum of nude mice. On the contralateral side of the dorsum, platelet-enriched fibrin glue/bone marrow mesenchymal stem cells/BMP-2 composites were injected. Bone formation was evaluated after 12 weeks.ResultsThe volumes of subcutaneous nodules formed in nude mice were 55 ± 18 μL at the PRP/bone marrow mesenchymal stem cells/BMP-2 sites and 135 ± 27 μL at the platelet-enriched fibrin glue/bone marrow mesenchymal stem cells/BMP-2 sites. Histomorphometric analysis demonstrated that the nodules contained 14.9 ± 4.1% newly formed bone when using PRP and 19.8 ± 3.6% newly formed bone when using platelet-enriched fibrin glue.ConclusionThe results indicated that the osteogenic characteristics of platelet-enriched fibrin glue are superior to PRP in bone tissue engineering.
Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology - Volume 102, Issue 2, August 2006, Pages 175–179