کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
32008 | 44875 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study](/preview/png/32008.png)
چکیده انگلیسی
We have developed a pathway design and optimization scheme that accommodates genetically and/or environmentally derived operational constraints. We express the full set of theoretically optimal pathways in terms of the underlying elementary flux modes and then examine the sensitivity of the optimal yield to a wide class of physiological perturbations. Though the scheme is general it is best appreciated in a concrete context: we here take succinate production as our model system. The scheme produces novel pathway designs and leads to the construction of optimal succinate production pathway networks. The model predictions compare very favorably with experimental observations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolic Engineering - Volume 8, Issue 1, January 2006, Pages 46–57
Journal: Metabolic Engineering - Volume 8, Issue 1, January 2006, Pages 46–57
نویسندگان
Steven J. Cox, Sagit Shalel Levanon, Ailen Sanchez, Henry Lin, Brad Peercy, George N. Bennett, Ka-Yiu San,