کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3214582 | 1203307 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peptidylarginine deiminases and deimination in biology and pathology: Relevance to skin homeostasis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Peptidylarginine deiminases and deimination in biology and pathology: Relevance to skin homeostasis Peptidylarginine deiminases and deimination in biology and pathology: Relevance to skin homeostasis](/preview/png/3214582.png)
چکیده انگلیسی
SummaryDeimination corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Catalyzed by peptidylarginine deiminases, it decreases the net positive charge of proteins, alters intra and intermolecular ionic interactions and probably the folding of target proteins. Deimination has recently been implicated in several physiological and pathological processes. Here, we describe the enzymes involved in this post-translational modification, focusing on their expression, location and roles in skin, as well as their known protein substrates in the epidermis and hair follicles. We discuss also the potential involvement of deimination in human diseases including cutaneous disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 44, Issue 2, November 2006, Pages 63–72
Journal: Journal of Dermatological Science - Volume 44, Issue 2, November 2006, Pages 63–72
نویسندگان
Stéphane Chavanas, Marie-Claire Méchin, Rachida Nachat, Véronique Adoue, Fanny Coudane, Guy Serre, Michel Simon,