کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
322694 540215 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats
ترجمه فارسی عنوان
محروم شدن خواب هوموستاز انرژی را از طریق تغییرات غیر جبرانی در گیرنده های انسولین هیپوتالاموس در موش های صحرایی ویستار
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• Paradoxical sleep deprivation increases food intake only during the light phase.
• Paradoxical sleep deprivation decreased insulin and leptin plasma levels.
• Paradoxical sleep deprivation increased expression of hypothalamic leptin receptors.

Studies have shown a gradual reduction of sleep time in the general population, accompanied by increased food intake, representing a risk for developing obesity, type II diabetes and cardiovascular disease. Rats subjected to paradoxical sleep deprivation (PSD) exhibit feeding and metabolic alterations, both of which are regulated by the communication between peripheral signals and the hypothalamus. This study aimed to investigate the daily change of 96 h of PSD-induced food intake, body weight, blood glucose, plasma insulin and leptin concentrations and the expression of their receptors in the hypothalamus of Wistar rats. Food intake was assessed during the light and dark phases and was progressively increased in sleep-deprived animals, during the light phase. PSD produced body weight loss, particularly on the first day, and decreased plasma insulin and leptin levels, without change in blood glucose levels. Reduced leptin levels were compensated by increased expression of leptin receptors in the hypothalamus, whereas no compensations occurred in insulin receptors. The present results on body weight loss and increased food intake replicate previous studies from our group. The fact that reduced insulin levels did not lead to compensatory changes in hypothalamic insulin receptors, suggests that this hormone may be, at least in part, responsible for PSD-induced dysregulation in energy metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 66, Issue 5, November 2014, Pages 705–712
نویسندگان
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