کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323040 540475 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Subcaste differences in neural activation suggest a prosocial role for oxytocin in eusocial naked mole-rats
ترجمه فارسی عنوان
تفاوت درجات فرعی در فعال سازی عصبی حاکی از نقش جامعه پسند برای اکسیتوسین در موش مول برهنه eusocial
کلمات کلیدی
اکسی توسین؛ Eusocial؛ موش مول برهنه؛ C-fos ؛ موقعیت اجتماعی؛ درجات فرعی؛ اجتماعی؛ تجاوز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• We compared behavior and oxytocin neural activity between naked mole-rat sub-castes.
• Soldiers were more aggressive than workers during a resident/intruder paradigm.
• Workers exhibited greater oxytocin neural activity than soldiers in this paradigm.
• Sub-caste is a significant predictor of oxytocin neural activity.

The neuropeptide oxytocin (OT) influences prosocial behavior(s), aggression, and stress responsiveness, and these diverse effects are regulated in a species- and context-specific manner. The naked mole-rat (Heterocephalus glaber) is a unique species with which to study context-dependent effects of OT, exhibiting a strict social hierarchy with behavioral specialization within the subordinate caste: soldiers are aggressive and defend colonies against unfamiliar conspecifics while workers are prosocial and contribute to in-colony behaviors such as pup care. To determine if OT is involved in subcaste-specific behaviors, we compared behavioral responses between workers and soldiers of both sexes during a modified resident/intruder paradigm, and quantified activation of OT neurons in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) using the immediate-early-gene marker c-fos co-localized with OT neurons. Resident workers and soldiers were age-matched with unfamiliar worker stimulus animals as intruders, and encounters were videorecorded and scored for aggressive behaviors. Colony-matched controls were left in their home colony for the duration of the encounters. Brains were extracted and cell counts were conducted for OT immunoreactive (ir), c-fos-ir, and percentage of OT-c-fos double-labeled cells. Results indicate that resident workers were less aggressive but showed greater OT neural activity than soldiers. Furthermore, a linear model including social treatment, cortisol, and subcaste revealed that subcaste was the only significant predictor of OT-c-fos double-labeled cells in the PVN. These data suggest that in naked mole-rats OT promotes prosocial behaviors rather than aggression and that even within subordinates status exerts robust effects on brain and behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 79, March 2016, Pages 1–7
نویسندگان
, , , , ,