کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323557 540706 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cross-sex pattern of bone mineral density in early onset gender identity disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Cross-sex pattern of bone mineral density in early onset gender identity disorder
چکیده انگلیسی

Hormonally controlled differences in bone mineral density (BMD) between males and females are well studied. The effects of cross-sex hormones on bone metabolism in patients with early onset gender identity disorder (EO-GID), however, are unclear. We examined BMD, total body fat (TBF) and total lean body mass (TLBM) in patients prior to initiation of sex hormone treatment and during treatment at months 3 and 12. The study included 33 EO-GID patients who were approved for sex reassignment and a control group of 122 healthy Norwegians (males, n = 77; females, n = 45). Male patients (n = 12) received an oral dose of 50 μg ethinylestradiol daily for the first 3 months and 100 μg daily thereafter. Female patients (n = 21) received 250 mg testosterone enantate intramuscularly every third week. BMD, TBF and TLBM were estimated using dual energy X-ray absorptiometry (DXA). In male patients, the DXA measurements except TBF were significantly lower compared to their same-sex control group at baseline and did not change during treatment. In female patients, the DXA measurements were slightly higher than in same-sex controls at baseline and also remained unchanged during treatment. In conclusion, this study reports that body composition and bone density of EO-GID patients show less pronounced sex differences compared to controls and that bone density was unaffected by cross-sex hormone treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 52, Issue 3, September 2007, Pages 334–343
نویسندگان
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