کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323689 540749 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cannabinoid–hormone interactions in the regulation of motivational processes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Cannabinoid–hormone interactions in the regulation of motivational processes
چکیده انگلیسی

There is a bi-directionality in hormone–cannabinoid interactions: cannabinoids affect prominent endocrine axes (such as the hypothalamic–pituitary–gonadal), and gonadal hormones modulate cannabinoid effects. This review will summarize recent research on these interactions, with a specific focus upon their implications for motivated behavior. Sexual behavior will serve as a “case study.” I will explore the hypothesis that ovarian hormones, in particular estradiol, may serve to release estrous behavior from endocannabinoid inhibition. Hormonal regulation of the endogenous cannabinoid system also affects processes that underlie drug abuse. This review will briefly discuss sex differences in behavioral responses to cannabinoids and explore potential mechanisms by which gonadal hormones alter cannabinoid reward. An examination of this research informs our perspective on how hormones and endocannabinoids may affect drug-seeking behavior as a whole and the development of addiction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 58, Issue 1, June 2010, Pages 100–110
نویسندگان
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