کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3245598 1589109 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Severity of Bleeding and Mortality in Trauma Patients Taking Dabigatran
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
The Severity of Bleeding and Mortality in Trauma Patients Taking Dabigatran
چکیده انگلیسی

BackgroundDabigatran, a direct thrombin inhibitor, has been shown to be more effective than warfarin in the prevention of stroke in patients with atrial fibrillation. Until recently, it lacked a reversal agent, and its contribution to the risk of transfusion in injured patients is unknown.ObjectiveWe sought to determine whether patients who sustain traumatic injuries while taking dabigatran receive more blood transfusions than matched patients taking warfarin, aspirin, clopidogrel, or controls.MethodsThis retrospective, single-center cohort consisted of injured patients who were taking dabigatran before admission to a major trauma center (January 2010–December 2013) who were compared with cohorts of patients taking warfarin, clopidogrel, or aspirin and a control group. The outcome was bleeding risk as measured by the use of blood products, with mortality as a secondary outcome. Outcomes were controlled for by age, sex, injury severity, and blunt mechanism.ResultsThirty-eight patients were taking dabigatran. Compared with the general trauma population, patients taking dabigatran were more likely to be male, older, and to have higher injury severity. Patients taking dabigatran received transfusions (odds ratio [OR] 1.31 [95% confidence interval {CI} 0.56–3.04]), packed red blood cells (OR 1.43 [95% CI 0.54–3.77]), frozen plasma (OR 1.20 [95% CI 0.42–3.49]), and platelets (OR 2.01 [95% CI 0.63–6.37]) as often as matched controls. The mortality rate among patients on dabigatran was 12.5% (OR 1.51 [95% CI 0.39–5.89]) compared with 9.1% in matched controls. None of these results was statistically significant.ConclusionsIn this small study, injured patients taking dabigatran were transfused as often and had similar in-hospital mortality as matched controls who were not taking anticoagulants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Emergency Medicine - Volume 51, Issue 3, September 2016, Pages 238–245
نویسندگان
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