Detection and management of late-onset 21-hydroxylase deficiency in women with hyperandrogenism

Moderate forms of 21-hydroxylase deficiency (D21OH-NC), the so-called non-classical or late-onset forms are a frequently reported cause of hyperandrogenism in women [1], [2], [3], [4] and [5]. The purpose of this collective and synthetic work was to provide the endocrinologist, gynecologist and dermatologist with consensual information so as to detect the maximum cases with acceptable cost–benefit ratio and to define the main lines of optimal patient management, given the data currently available in medical literature.