کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3254070 1207175 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma
چکیده انگلیسی

Helicobacter pylori infection is the major etiological factor of gastric carcinoma. This disease is the result of a long, multistep, and multifactorial process, which occurs only in a small proportion of patients infected with H. pylori. Gastric carcinoma development is influenced by host genetic susceptibility factors, environmental factors, and H. pylori virulence. H. pylori is genetically highly variable, and variability that affects H. pylori virulence factors may be useful to identify strains with different degrees of pathogenicity. This review will focus on VacA and CagA that have polymorphic regions that impact their functional properties. The characterization of H. pylori vacA and cagA-associated could be useful for identifying patients at highest risk of disease, who could be offered H. pylori eradication therapy and who could be included in programs of more intensive surveillance in an attempt to reduce gastric carcinoma incidence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Gastroenterology - Volume 28, Issue 6, December 2014, Pages 1003–1015
نویسندگان
, , ,