کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3259078 1207566 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Associations between the common HNF1A gene variant p.I27L (rs1169288) and risk of type 2 diabetes mellitus are influenced by weight
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Associations between the common HNF1A gene variant p.I27L (rs1169288) and risk of type 2 diabetes mellitus are influenced by weight
چکیده انگلیسی

AimThe common variants p.I27L (rs1169288), p.A98V (rs1800574) and p.S487N (rs2464196) of the hepatocyte nuclear factor 1-α (HNF1A) gene have been inconsistently associated with impaired glucose tolerance and/or an increased risk of type 2 diabetes mellitus (T2DM). The present study aimed to investigate whether these associations are affected by weight.MethodsA cross-sectional analysis was conducted among 861 Japanese subjects (males: 65.5%; 61.8 ± 12.3 years) attending a health-screening programme. Interactive effects between HNF1A variants and weight status on risk of T2DM or dysglycaemic status were determined.ResultsThe 27L variant carriers were at higher risk of T2DM and dysglycaemic status than non-carriers, but only in normal-weight subjects [odds ratio (OR): 2.04, P = 0.03 and OR: 2.56, P = 0.01, respectively]. An interactive effect of the p.I27L (rs1169288) variant and weight status on the risk of dysglycaemic status was found (P = 0.04). Age, but not body mass index (BMI), was a risk factor for dysglycaemic status in the 27L carriers (OR: 1.05, P = 0.0003), whereas BMI was a risk factor in non-carriers (OR: 1.23, P = 0.008). No carriers of 98V were identified, and 487N was not associated with either T2DM or dysglycaemic status in our study population.ConclusionThese findings suggest that the HNF1A p.I27L (rs1169288) variant may be a significant risk factor of T2DM in normal-weight subjects and that earlier inconsistent results may have been due, in part, to subjects’ weight status. Further investigations in larger cohorts are needed to verify these findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolism - Volume 41, Issue 1, February 2015, Pages 91–94
نویسندگان
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