کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
326039 1644947 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes of Pain Perception, Autonomic Function, and Endocrine Parameters During Treatment of Anorectic Adolescents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Changes of Pain Perception, Autonomic Function, and Endocrine Parameters During Treatment of Anorectic Adolescents
چکیده انگلیسی

ABSTRACTObjectivesThe underlying mechanisms of reduced pain perception in anorexia nervosa (AN) are unknown. To gain more insight into the pathology, the authors investigated pain perception, autonomic function, and endocrine parameters before and during successful treatment of adolescent AN patients.MethodHeat pain perception was assessed in 15 female adolescent AN patients and matched controls. Results were correlated with autonomic and endocrine parameters (free triiodothyronine, free cortisol). Autonomic function was studied using heart rate variability and pupillary light reflex assessment. To investigate the influence of therapy on these parameters, data were obtained at three different time points.ResultsHeat pain thresholds were significantly increased in the acute state and decreased after weight had been regained for 6 months. Similarly, an increased parasympathetic tone was present in the acute state only. The relative amplitude of the pupillary light reflex showed a positive correlation to pain thresholds over time and predicted disease progression. In addition, the authors found a negative correlation between increased pain thresholds and low free cortisol.ConclusionIncreased pain thresholds are associated with increased parasympathetic tone and a hypothyroid state in AN. This may either indicate common central mechanisms or suggest a causative interaction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Child & Adolescent Psychiatry - Volume 45, Issue 9, September 2006, Pages 1068–1076
نویسندگان
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