A phase I study of continuous hepatic arterial infusion of Irinotecan in patients with locally advanced hepatocellular carcinoma

PurposeAim of this phase I study was to identify the maximum tolerated dose and dose limiting toxicity of continuous infusion of Irinotecan through a port-a-cath placed in the hepatic artery in patients with hepatocellular carcinoma and cirrhosis to explore new strategies in advanced hepatocellular carcinoma. Response rate and time-to-progression were analysed.MethodsIrinotecan was delivered as a five-day continuous infusion every 21 days, with increases of 2.5 mg/m2/day every three patients, starting from 7.5 mg/m2/day. Dose limiting toxicity corresponded to one patient in each triplet developing G4 haematological or G3 non-haematological toxicity, confirmed in two triplets. Twenty-eight patients (17 Child-Pugh A, 11 B) received treatment and tumour response was assessed after three courses completed by 22 patients.ResultsDose limiting toxicity was G3 diarrhoea in two patients, reached at 27.5 mg/m2/day and the recommended dose was set at 25 mg/m2/day. Nineteen of 30 patients experienced adverse events related to porth-a-cath placement and one died from liver ischemia and sepsis. Median time-to-progression was 11.3 months.ConclusionIntrarterial infusion of Irinotecan is feasible in patients with hepatocellular carcinoma on cirrhosis at a recommended dose of 25 mg/m2/day, with no major adverse drug-related events, but with some concerns about the insertion and management of the intra-arterial device.