کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3264943 1207798 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A common CTLA4 polymorphism confers susceptibility to Autoimmune Thyroid Disease in celiac children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
A common CTLA4 polymorphism confers susceptibility to Autoimmune Thyroid Disease in celiac children
چکیده انگلیسی

BackgroundCytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a strong candidate gene in autoimmunity susceptibility. In particular, the CTLA4 CT60 A/G dimorphism has been associated with celiac disease (CD) and was reported to be strongly associated with autoimmune thyroid disease (AITD).AimsThis study aimed to investigate the possible influences of the CTLA4 CT60 A/G polymorphism in the susceptibility of Italian children to CD and in the predisposition to develop AITD in children with CD.Patients and methodsWe genotyped 317 Italian celiac children, including 44 patients (13.9%) who developed AITD after CD diagnosis and 350 controls.ResultsThe CTLA4 CT60 GG genotype distribution did not show any significant difference between children with CD and control population (p = 0.4). On the contrary, the frequency of the GG genotype was significantly higher in patients with CD complicated with AITD than in control subjects (p = 0.002) and CD patients without AITD (p = 0.02).ConclusionOur data show a significant effect of the CTLA4 CT60G allele at the homozygous state on the risk of developing AITD in children with CD and suggest that the reported association of the CTLA4 CT60 A/G polymorphism with CD is limited to the subgroup of patients who are or will be complicated with AITD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 41, Issue 6, June 2009, Pages 385–389
نویسندگان
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