کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3270410 1589608 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T-cell protein tyrosine phosphatase: A role in inflammation and autoimmunity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
T-cell protein tyrosine phosphatase: A role in inflammation and autoimmunity
چکیده انگلیسی

A cDNA of PTPN2 encoding for T-cell protein tyrosine phosphate (TC-PTP) was isolated and characterized as long as 20 years ago. However, findings suggesting a potentially exciting role of this enzyme in general autoimmunity have only recently been obtained. Genome-wide association scans of the human genome revealed the involvement of PTPN2 in susceptibility to a several autoimmune disorders such as Crohn’s disease, type 1 diabetes, and Graves’ disease. Functional studies in immune cells revealed a key role of this enzyme in down-regulation of cytokine expression and inflammatory response, which provides an essential background to explaining the pathophysiological role of TC-PTP in autoimmunity. Thus, in addition to PTPN22, PTPN2 is likely to represent a second member of the broad family of non-receptor PTPs contributing to general autoimmunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Diabetes Mellitus - Volume 2, Issue 2, August 2010, Pages 114–118
نویسندگان
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