کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3273284 | 1208385 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Néoplasies lobulaires intra-épithéliales : hyperplasie lobulaire atypique et cancer lobulaire in situ
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
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چکیده انگلیسی
Intra-epithelial lobular neoplasias (ILN) are non invasive proliferations within the terminal ducto-lobular unit of monomorphic loosely cohesive small cells. A lack of expression of the E-cadherin adhesion molecule is often observed as in invasive lobular breast cancer. ILN are infrequent, however, a rise in incidence partly, due to the generalization of mammographic screening, is observed. Actually ILN are usually asymptomatic and diagnosed after breast biopsy for unspecified microcalcifications. ILN are associated with an increased risk of breast cancer that persists over 20Â years after the initial diagnosis. The average risk is 4.2Â % for the ipsilateral breast and 3,5Â % for the controlateral breast. However, a great variability in the risk estimation is observed between the studies. There is no consensus on how to treat ILN. Surgical options have varied from biopsy to bilateral mastectomy. Current tendency is favouring lumpectomy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal de Gynécologie Obstétrique et Biologie de la Reproduction - Volume 39, Issue 2, April 2010, Pages 91-101
Journal: Journal de Gynécologie Obstétrique et Biologie de la Reproduction - Volume 39, Issue 2, April 2010, Pages 91-101
نویسندگان
Y. Ansquer, P. Santulli, C. Colas, M. Jamali, C. Tournigand, L. Duperray, B. Duperray, D. Jannet, B. Carbonne,