کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
327428 542877 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased PLA2 activity in the hippocampus of patients with temporal lobe epilepsy and psychosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Increased PLA2 activity in the hippocampus of patients with temporal lobe epilepsy and psychosis
چکیده انگلیسی

ObjectiveThe aim of this work was to investigate whether increased activity of the enzyme phospholipase A2 (PLA2) in the brain, as frequently reported in schizophrenia, is also related to psychosis in epilepsy. Our working hypothesis was based on the increased prevalence of schizophrenia-like psychosis in patients with temporal lobe epilepsy (TLE) secondary to mesial temporal sclerosis (MTS), as compared to patients with other forms of epilepsy.MethodsWe determined PLA2 activity in hippocampal tissue from 7 patients with TLE-MTS and psychosis, as compared to 9 TLE-MTS patients without psychosis. Hippocampal tissue was obtained from patients who underwent an anterior temporal lobectomy due to therapy-resistant epilepsy.ResultsWe found that patients with TLE-MTS and psychosis had a significantly increased calcium-independent PLA2 activity as compared to patients without psychosis (p = 0.016).ConclusionOur finding suggest that an increment in brain PLA2 activity is not specific for schizophrenia, but rather may be associated to the manifestation of schizophrenia-like psychotic symptoms in general.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 45, Issue 12, December 2011, Pages 1617–1620
نویسندگان
, , , , ,